Antimicrobial Discovery.

 

Current efforts: discovering inhibitors of c-di-GMP signaling pathway.

Publications: Secretion inhibitors

Kline, T., Felise, H. B., Sanowar, S., Miller, S. I. The Type III Secretion Systemas a Source of Novel Antibactrial Drug Targets. Current Drug Targets. accepted for publication 2011.

Felise, H. B., Kline, T., Miller, S. I. Targeting Bacterial Secretion Systems for the Development of Novel Therapeutic Agents, in Emerging Trends in Antibacterial Discovery, Alita A. Miller and Paul F. Miller, editors, Horizon Scientific Press, Norwich UK (2011)

Kline, T., Barry, K. C., Jackson, S. R., Felise, H. B., Nguyen, H. V., Miller, S. Tethered Thiazolidinone

Dimers as Inhibitors of the Bacterial Type III Secretion System, Bioorg. Med.Chem. Letters 19, 1340-1343 (2009).

Kline, T., Felise, H. B., Barry, K. C., Jackson, S. R., Nguyen, H. V., Miller, S. I. Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion. J. Med. Chem. 51, 7065-7074 (2008).

Felise, H. B., Nguyen, H. V., Pfeutzner, R. A., Barry, K. C., Jackson, S. R., Blanc, M. P., Bronstein, P. A. Kline, T., Miller, S. I. An Inhibitor of Gram-negative Bacterial Virulence Protein Secretion. Cell Host Microbe 4, 324-336 (2008).

publications for c-di-GMP

Kline, T., Jackson, S. R., Wei, D., Verlinde, C L. M. J., Miller, S. I. Design and Synthesis of bis-Carbamate

Analogs of Cyclic bis-(3’-5’)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer pGpG. Nucleosides, Nucleotides, and Nucleic Acids 27, 1282-1300 (2008).

publications for lipid A

Kline, T., Trent, M. S., Stead, C. M., Lee, M. S., Sousa, M. C., Felise, H. B., Nguyen, H. V., Miller S. I.

Synthesis of and Evaluation of Lipid A Modification by 4-substituted 4-Deoxy Arabinose Analogs as Potential Inhibitors of Bacterial Polymyxin Resistance. Bioorg. Med. Chem. Letters. 18, 1507-1510 (2008).