Education: P.D., Ph.D
Areas of interest:
– Resistance of Pseudomonas aeruginosa to antibiotics by production of β-lactamases and efflux pumps. Characterization of new enzymes, detection of resistance mechanisms in the clinical laboratory, epidemiology.
– Adaptation of Pseudomonas aeruginosa during the infection (current project, granted by a Marie Curie fellowship from the European Community). We are characterizing melanogenic clinical isolates of P. aeruginosa, that regularly emerge in chronically-infected patients, especially those suffering from cystic fibrosis. The genome sequencing of wild-type clinical isolates and their melanogenic derivatives will identify the missing genes and help to address the genetic mechanism by which the deletion occurs. The new properties of the mutants were assessed using phenotypic microarrays (Biolog, Inc.).
Publications: link to Pubmed
Educational website (in French): Bacterioweb