Senior Research Scientist
University of Washington
HSB, Box J112
Seattle, WA 98195
Computational approaches to solving problems in bacterial pathogenesis is the overarching theme of my research. Novel methods for the discovery of previously unknown virulence genes interests me the most. I have pursued several projects to find a methodology for characterizing effectors and their chaperones in order to filter genomic data in search of candidates for experimental analysis. These methods include the use of protein properties such as hydrophobicity and amphipathicity, codon or peptide usage statistics and common regulatory promoter sites.
Another area of interest is visualization methods for integrating heterogeneous data. In particular, I am looking for new ways to display expression data from microarrays and proteomics along with genome sequence and annotation. The purpose of this project is to aid investigators in comprehending experimental results that encompass large data sets that spans many protein metabolic pathways and functions.
Ernst et al. (2003) Environmental Microbiology, 5(12):1341-9.
Miao, E. A., M. Brittnacher, A. Haraga, R. L. Jeng, M. D. Welch, and S. I. Miller, Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton, Molecular Microbiology, 48(2), 401-15, 2003.
Brittnacher, M., and E. C. Whipple, Extension of the Harris magnetic field model to obtain exact, two-dimensional, self-consistent X-point structures, Journal of Geophysical Research, 107, SMP3-1, 2002.
Brittnacher, M., J. Kang, G. K. Parks, R. K. Elsen, G. A. Germany, J. F. Spann, N. Fox, R. C. Puetter, A. Yahil, Far-ultraviolet observations of the neutral coma of Comet Hale-Bopp near Perihelion, Geophysical Research Letters, 28, 2561, 2001.
M. Brittnacher, M. Fillingim, G. Parks, G. Germany, and J. Spann, Polar cap area and boundary motion during substorms, Journal of Geophysical Research, 104, 12,251-62, 1999.
Parks, G. K., M. Brittnacher, R. K. Elsen, M. McCarthy, J. M. O’Meara, G. Germany, and J. Spann, Comparison of dark pixels observed by VIS and UVI in dayglow images, Geophysical Research Letters, 25, 3063, 1998.
Brittnacher, M., K. B. Quest, H. Karimabadi, A study of the effect of pitch angle and spatial diffusion on tearing instability using a new finite element based linear code, Journal of Geophysical Research, in press, 1998.
Parks, G. K., M. Brittnacher, L. J. Chen, R. K. Elsen, M. McCarthy, G. Germany, and J. Spann, Does the UVI on Polar detect cosmic snowballs?, Geophysical Research Letters, 24, 3109 1997.
Brittnacher, M., J. Spann, G. Parks, and G. Germany, Auroral observations by the Polar Ultraviolet Imager UVI, Advances in Space Research, 20, 1037-1042, 1997.
Brittnacher, M., R. Elsen, G. Parks, L. Chen, G. Germany, and J. Spann, A dayside auroral energy deposition case study using the Polar Ultraviolet Imager, Geophysical Research Letters, 24, 991-994, 1997.
Brittnacher, M., A linear analysis of tearing instability in magnetotail equilibria using simulation and numerical methods, Ph.D. Dissertation, UCSD, 1995
Brittnacher, M., K. B. Quest, and H. Karimabadi, A new approach to the linear theory of single-species tearing in two-dimensional quasineutral sheets, Geophysical Research, 100, 3551-3562, 1995.
Brittnacher, M., K. B. Quest, and H. Karimabadi, On the energy principle and ion tearing in the magnetotail, Geophysical Research Letters, 21, 1591-1594, 1994.
Brittnacher, M., and E. C. Whipple, Chaotic jumps in the generalized first adiabatic invariant in current sheets, Geophysical Research Letters, 18, 1599-1602, 1991.